PF 184

• Catalog No.: P293750
• CAS Number: 1187460-81-6
• M. F.: C32H32ClFN6O4
• M. W.: 619.0856832

SYNONYMS

• IUPAC name: 2-[(3R,4S)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-N-[3-carbamoyl-1-(4-fluorophenyl)-1H,4H,5H-benzo[g]indazol-8-yl]-5-chloropyridine-4-carboxamide
• IUPAC Traditional name: 2-[(3R,4S)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-N-[3-carbamoyl-1-(4-fluorophenyl)-4H,5H-benzo[g]indazol-8-yl]-5-chloropyridine-4-carboxamide
• Synonyms: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

DATABASE IDS

• CAS Number: 1187460-81-6

DETAILS

Description (English)

PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress.

REFERENCES

• Baldwin, A., et al.: J. Clin. Invest., 107, 3 (2001)
• Adcock, I., et al.: Eur. J. Pharmacol., 533, 118 (2001)
• Sommers, et al.: J. Pharmacol. Exp. Ther., 330 377 (2001)