Perphenazine

• Catalog No.: P291100
• CAS Number: 58-39-9
• M. F.: C21H28O4
• M. W.: 344.44462
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (1S,2S,9R,10S,11S,14R,15S)-14-ethynyl-2-hydroperoxy-14-hydroxy-9,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• IUPAC Traditional name: (1S,2S,9R,10S,11S,14R,15S)-14-ethynyl-2-hydroperoxy-14-hydroxy-9,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadec-6-en-5-one
• Synonyms: 1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine; Chloriprozine; Thilatazin; Tranquisan; Fluphenazine Imp. E (Pharmeuropa); 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol; Chlorperphenazine; Decentan; Emesinal; Etaperazin; Perfenil; Perphenan; Perphenazin; Sch 3940; Trifaron

DATABASE IDS

• CAS Number: 58-39-9

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 95-98°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.

REFERENCES

• Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975)
• O Brien, S., et al.: J. Med. Chem., 48, 1287 (1975)
• Briggs, K., et al.: Toxicology, 231, 113 (1975)
• Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (1975)