Peplomycin Sulfate

• Catalog No.: P285250
• CAS Number: 70384-29-1
• M. F.: C61H90N18O25S3
• M. W.: 1571.6679

SYNONYMS

• IUPAC name: sulfuric acid (2R,3S,4S,5R,6R)-2-{[(2R,3S,4S,5S,6S)-2-{2-[(6-amino-2-{1-[(2-amino-2-carbamoylethyl)amino]-2-carbamoylethyl}-5-methylpyrimidin-4-yl)formamido]-2-({3-hydroxy-4-[(2-hydroxy-1-{[2-(4-{4-[(3-{[(1R)-1-phenylethyl]amino}propyl)carbamoyl]-1,3-thiazol-2-yl}-1,3-thiazol-2-yl)ethyl]carbamoyl}propyl)carbamoyl]-4-methylbutan-2-yl}carbamoyl)-1-(1H-imidazol-4-yl)ethoxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl carbamate
• IUPAC Traditional name: sulfuric acid (2R,3S,4S,5R,6R)-2-{[(2R,3S,4S,5S,6S)-2-{2-[(6-amino-2-{1-[(2-amino-2-carbamoylethyl)amino]-2-carbamoylethyl}-5-methylpyrimidin-4-yl)formamido]-2-({3-hydroxy-4-[(2-hydroxy-1-{[2-(4-{4-[(3-{[(1R)-1-phenylethyl]amino}propyl)carbamoyl]-1,3-thiazol-2-yl}-1,3-thiazol-2-yl)ethyl]carbamoyl}propyl)carbamoyl]-4-methylbutan-2-yl}carbamoyl)-1-(1H-imidazol-4-yl)ethoxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl carbamate
• Synonyms: N1-[3-[[(1S)-1-phenylethyl]amino]propyl]bleomycinamide Sulfate; Pepleo; NK 631; Pepleomycin Sulfate

DATABASE IDS

• CAS Number: 70384-29-1

PROPERTIES

• Apperance: Pale Yellow Amorphous Powder
• Melting Point: 196-198°C
• Solubility: DMSO
• Solubility: DMF
• Solubility: Methanol
• Solubility: Water

DETAILS

Description (English)

A derivative of Bleomycin with cytostatic activity and less pulmonary toxicity than the natural Bleomycin mixture.

REFERENCES

• Takahashi, K., et al.: J. Antibiot., 32, 36 (1979)
• Sikic, B.I., et al.: Cancer Treat. Rep., 64, 659 (1979)