Pentostatin

• Catalog No.: P227350
• CAS Number: 53910-25-1
• M. F.: C11H16N4O4
• M. W.: 268.26914
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (8R)-3-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol
• IUPAC Traditional name: (8R)-3-[(2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol
• Synonyms: PD-ADI; (8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol; 2'-DCF; 2'-Deoxycoformycin; Coforin; (R)-; CI 825; CL 67310465; Cl 825; Co-V; Co-Vidarabine; NSC 218321; NSC 247520; Nipent; Vira A Deaminase Inhibitor

DATABASE IDS

• CAS Number: 53910-25-1

PROPERTIES

• Apperance: White Solid
• Melting Point: 225-227°C
• Solubility: DMSO
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia.

REFERENCES

• Rogler-Brown, T. et al.: Biochem. Pharmacol., 28, 201 (1979)
• Johnston, J.B. et al.: J. Natl. Canvcer Inst., 80, 765 (1979)
• Fortune, A.F. et al.: Leuk. and Lymph., 51, 839 (1979)
• Robak, T. et al.: Drugs, 69, 2415 (1979)