Pemetrexed Disodium

• Catalog No.: P219500
• CAS Number: 150399-23-8
• M. F.: C20H19N5Na2O6
• M. W.: 471.3743
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: disodium (2R)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate
• IUPAC Traditional name: disodium (2R)-2-{[4-(2-{2-amino-4-oxo-1H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}pentanedioate
• Synonyms: Pemetrexed Sodium; Alimta; N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium; LY 231514; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Sodium Salt; LY 231514 Disodium; Rolazar; Tifolar

DATABASE IDS

• CAS Number: 150399-23-8

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 254-258°C (dec.)
• Solubility: Methanol
• Solubility: Water
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic.

REFERENCES

• McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998)
• John, W., et al.: Cancer, 88, 1807 (1998)
• Miller, K.D., et al.: Ann. Oncol., 11, 101 (1998)