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PD-173074_Molecular_structure_CAS_219580-11-7)
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PD-173074

Catalog No. P217700 Name Toronto Research Chemicals
CAS Number 219580-11-7 Website http://www.trc-canada.com
M. F. C28H41N7O3 Telephone +1 (416) 665-9696
M. W. 523.67024 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 72601

SYNONYMS

IUPAC name
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
IUPAC Traditional name
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
Synonyms
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
PD 173074

DATABASE IDS

CAS Number 219580-11-7

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point 98-100°C
Solubility Chloroform
Solubility Methanol
MSDS Link Download
Storage Condition Refrigerator

DETAILS

Description (English)
PD 173074 is a selective FGFR1 and FGFR3 inhibitor. PD 173074 is a compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.

REFERENCES

  • Mohammadi, M., et al.: Science, 276, 955 (1997)
  • Yagasaki, F., et al.: Cancer Res., 61, 8371 (1997)
  • Keats, J., et al.: Blood, 101, 1520 (1997)
  • Buchler, et al.: 9, 119 (1997)