PD-173074

• Catalog No.: P217700
• CAS Number: 219580-11-7
• M. F.: C28H41N7O3
• M. W.: 523.67024
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
• IUPAC Traditional name: 3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
• Synonyms: N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD 173074

DATABASE IDS

• CAS Number: 219580-11-7

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 98-100°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

PD 173074 is a selective FGFR1 and FGFR3 inhibitor. PD 173074 is a compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.

REFERENCES

• Mohammadi, M., et al.: Science, 276, 955 (1997)
• Yagasaki, F., et al.: Cancer Res., 61, 8371 (1997)
• Keats, J., et al.: Blood, 101, 1520 (1997)
• Buchler, et al.: 9, 119 (1997)