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PD-169316 _Molecular_structure_CAS_152121-53-4)
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PD-169316

Catalog No. P217600 Name Toronto Research Chemicals
CAS Number 152121-53-4 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]pyridine
IUPAC Traditional name
4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]pyridine
Synonyms
4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine
4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]pyridine

DATABASE IDS

CAS Number 152121-53-4

PROPERTIES

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DETAILS

Description (English)
PD 169316 is a highly selective, potent inhibitor of p38 MAP kinase. PD 169316 inhibits transforming growth factor β-induced Smad signaling in human ovarian cancer cells. PD 169316 acts as an an endogenous suppressor of apoptosis by mimicking CD9, a membr

REFERENCES

  • Fu, Y. et al.: Bioche,. Biophys. Res. Comm., 310, 391 (2003)
  • Krishnamoorthy, M. et al.: J. Biochem., 145, 177 (2003)
  • Schwertz, H. et al.: Proteomics, 7, 24 (2003)