PD-166285

• Catalog No.: P217500
• CAS Number: 212391-63-4
• M. F.: C26H27Cl2N5O2
• M. W.: 512.43088
• Storage: Hygroscopic, Refrigerator, Under inert atmosphere

SYNONYMS

• IUPAC name: 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
• IUPAC Traditional name: 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7-one
• Synonyms: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride

DATABASE IDS

• CAS Number: 212391-63-4

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 239-242°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, Refrigerator, Under inert atmosphere
• Storage Warning: Hygroscopic

DETAILS

Description (English)

A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).

REFERENCES

• Star, W., et al.: Cancer Res., 46, 2532 (1986)
• Sawutz, D., et al.: Biochem. Pharm., 51, 1631 (1986)
• Voest, E., et al.: Anti-Cancer Drugs, 7, 723 (1986)
• Connolly, C., et al.: Bioorg. Med. Chem. Lett., 7(1986)
• 2415 (1986)
• Hamby, J., et al.: J. Med. Chem.