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PD-166285_Molecular_structure_CAS_212391-63-4)
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PD-166285

Catalog No. P217500 Name Toronto Research Chemicals
CAS Number 212391-63-4 Website http://www.trc-canada.com
M. F. C26H27Cl2N5O2 Telephone +1 (416) 665-9696
M. W. 512.43088 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, Refrigerator, Under inert atmosphere Chembase ID: 176245

SYNONYMS

IUPAC name
6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
IUPAC Traditional name
6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methylpyrido[2,3-d]pyrimidin-7-one
Synonyms
6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride

DATABASE IDS

CAS Number 212391-63-4

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point 239-242°C
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition Hygroscopic, Refrigerator, Under inert atmosphere
Storage Warning Hygroscopic

DETAILS

Description (English)
A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).

REFERENCES

  • Star, W., et al.: Cancer Res., 46, 2532 (1986)
  • Sawutz, D., et al.: Biochem. Pharm., 51, 1631 (1986)
  • Voest, E., et al.: Anti-Cancer Drugs, 7, 723 (1986)
  • Connolly, C., et al.: Bioorg. Med. Chem. Lett., 7(1986)
  • 2415 (1986)
  • Hamby, J., et al.: J. Med. Chem.