PD-161570

• Catalog No.: P217490
• CAS Number: 192705-80-9
• M. F.: C26H35Cl2N7O
• M. W.: 532.5084
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea
• IUPAC Traditional name: 3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea
• Synonyms: 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea; N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

DATABASE IDS

• CAS Number: 192705-80-9

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 215-230°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells.

REFERENCES

• Batley, B.L. et al.: Life Sci., 62, 143 (1997)
• Hamby, J.M. et al.: J. Med. Chem., 40, 2296 (1997)
• Nandi, S. et al.: J. Enz. Inhib. Med. Chem., 24, 937 (1997)