PD-149163

• Catalog No.: P217480
• CAS Number: 169528-11-4
• M. F.: C42H71N9O6
• M. W.: 798.06984

SYNONYMS

• IUPAC name: ethyl (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-6-amino-2-{[(2S)-2,6-diaminohexyl]amino}hexanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]-3,3-dimethylbutanamido]-4-methylpentanoate
• IUPAC Traditional name: ethyl (2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-6-amino-2-{[(2S)-2,6-diaminohexyl]amino}hexanoyl]pyrrolidin-2-yl]formamido}-3-(1H-indol-3-yl)propanamido]-3,3-dimethylbutanamido]-4-methylpentanoate
• Synonyms: (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester; PF-01472472; N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester

DATABASE IDS

• CAS Number: 169528-11-4

DETAILS

Description (English)

PD 149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists such as PD 149163 block the prepulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD 149163 shows pro-cognitive, antipsychotic

REFERENCES

• Feifel, D. et al.: Neuropsychophamacology, 28, 651 (2003)
• Shilling, P.D. et al.: Psychopharmacolgy, 175, 353 (2003)