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PD-0235901

Catalog No. P217450 Name Toronto Research Chemicals
CAS Number 391210-10-9 Website http://www.trc-canada.com
M. F. C16H14F3IN2O4 Telephone +1 (416) 665-9696
M. W. 482.1930396 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer, Under Inert Atmosphere Chembase ID: 4754

SYNONYMS

IUPAC name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
IUPAC Traditional name
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Synonyms
PD 0325901
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

DATABASE IDS

CAS Number 391210-10-9

PROPERTIES

Certificate of Analysis Download
Apperance White to Off-White Solid
Melting Point 112-114°C
Solubility DMSO
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor; has potent activity in a no. of cancer cell types in vitro.

REFERENCES

  • Davies, H., et al.: Nature, 417, 949 (2002)
  • Wellbrock, C., et al.: Cancer Res., 64, 2338 (2002)
  • Solit, D., et al.: Cancer Res., 67, 11463 (2002)
  • Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2002)