Pamapimod-d4

• Catalog No.: P167502
• M. F.: C19H20F2N4O4
• M. W.: 406.3833064

SYNONYMS

• IUPAC name: 6-(2,4-difluorophenoxy)-2-{[1,5-dihydroxy(1,1,5,5-^2H₄)pentan-3-yl]amino}-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
• IUPAC Traditional name: 6-(2,4-difluorophenoxy)-2-{[1,5-dihydroxy(1,1,5,5-^2H₄)pentan-3-yl]amino}-8-methylpyrido[2,3-d]pyrimidin-7-one
• Synonyms: Ro 4402257-d4; R 1503-d4; 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one-d4

DETAILS

Description (English)

Labelled Pamapimod. A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.

REFERENCES

• Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998)
• Lee, J., et al.: Pharmacol. Ther., 82, 389 (1998)
• Korb, A., et al.: Arthritis Rheum., 54, 2745 (1998)