(S,S)-Palonosetron Hydrochloride

• Catalog No.: P165800
• CAS Number: 135729-62-3
• M. F.: C19H25ClN2O
• M. W.: 332.8676
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (5S)-3-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3-azatricyclo[7.3.1.0^5,^1^3]trideca-1(12),9(13),10-trien-2-one hydrochloride
• IUPAC Traditional name: palonosetron hydrochloride hydrochloride
• Synonyms: (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; Onicit; Aloxi; RS-25259-197

DATABASE IDS

• CAS Number: 135729-62-3

PROPERTIES

• Apperance: White Solid
• Melting Point: 238-244°°C
• Solubility: DMSO
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Refrigerator

DETAILS

Description (English)

Serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.

REFERENCES

• Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993)
• Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1993)
• Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (1993)
• Eisenberg, P., et al.: Ann. Oncol., 15, 330 (1993)
• Siddiqui, M.A.A., et al