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PAC-1-d8
Catalog No.	P132002	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C23H28N4O2	Telephone	+1 (416) 665-9696
M. W.	392.49402	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 176152

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SYNONYMS

IUPAC name

2-[4-benzyl(²H₈)piperazin-1-yl]-N'-[(1E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene]acetohydrazide

IUPAC Traditional name

2-[4-benzyl(²H₈)piperazin-1-yl]-N'-[(1E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene]acetohydrazide

Synonyms

4-(Phenylmethyl)-1-(piperazine-d8)acetic Acid (2E)-2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executio

REFERENCES

Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001)
Pop, C., et al.: Biochemistry, 42, 12311 (2001)
Li, L., et al.: Science, 305, 1471 (2001)
Green, D., et al.: J. Clin. Invest., 115, 2610 (2001)
Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2001)