Oxamflatin

• Catalog No.: O845090
• CAS Number: 151720-43-3
• M. F.: C17H14N2O4S
• M. W.: 342.36906
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2E)-5-(3-benzenesulfonamidophenyl)-N-hydroxypent-2-en-4-ynamide
• IUPAC Traditional name: (2E)-5-(3-benzenesulfonamidophenyl)-N-hydroxypent-2-en-4-ynamide
• Synonyms: (2E)-5-[3-(Phenylsulfonylamino)phenyl]pent-2-en-4-ynohydroxamic Acid; (2E)-N-Hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2-penten-4-ynamide

DATABASE IDS

• CAS Number: 151720-43-3

PROPERTIES

• Apperance: Red-Brown Solid
• Melting Point: 98-100°C
• Solubility: DMSO
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.

REFERENCES

• Ohtani, M., et al.: J. Med. Chem., 39, 2871 (1996)
• Dear, A.E., et al.: Biochem. Biophys. Acta, 1492, 15 (1996)
• Lavoie, R., et al.: Bioorg. Med. Chem. Lett., 11, 2847 (1996)