Otamixaban

• Catalog No.: O712500
• CAS Number: 193153-04-7
• M. F.: C25H26N4O4
• M. W.: 446.49834

SYNONYMS

• IUPAC name: 4-(4-{[(2R,3R)-3-[(3-carbamimidoylphenyl)methyl]-4-methoxy-4-oxobutan-2-yl]carbamoyl}phenyl)pyridin-1-ium-1-olate
• IUPAC Traditional name: otamixaban
• Synonyms: Methyl (2R,3R)-2-[3-Amidinobenzyl]-3-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]butanoate; (αR)-3-(Aminoiminomethyl)-α-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]benzenepropanoic Acid Methyl Ester; FXV 673; [R-(R*,R*)]-3-(Aminoiminomethyl)-α-[1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]benzenepropanoic Acid Methyl Ester

DATABASE IDS

• CAS Number: 193153-04-7

DETAILS

Description (English)

A potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. Clinical studies show that it is efficacious, safe and well tolerated in humans and therefore has c

REFERENCES

• Guertin, K.R. et al.: Curr. Med. Chem., 14, 2471 (2007)
• Hinder, M. et al.: Clin. Pharmacol. Therap., 80, 691 (2007)
• Hinder, M. et al.: Thromb. Haemost., 95, 224 (2007)