NVP-BEZ 235

• Catalog No.: N925750
• CAS Number: 915019-65-7
• M. F.: C30H23N5O
• M. W.: 469.53652
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
• IUPAC Traditional name: 2-methyl-2-{4-[3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile
• Synonyms: BEZ 235; 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-benzeneacetonitrile; 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile

DATABASE IDS

• CAS Number: 915019-65-7

PROPERTIES

• Apperance: Light Beige Solid
• Melting Point: 288-289°C
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR.

REFERENCES

• Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009)
• Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009)
• Pollizzi, K., et al.: Mol. Cancer, 8 (2009)