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NSC-33994-d4
Catalog No.	N900302	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C28H42N2O2	Telephone	+1 (416) 665-9696
M. W.	438.64528	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 175745

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SYNONYMS

IUPAC name

2-[(diethylamino)(²H₂)methyl]-4-[(3E)-4-{3-[(diethylamino)(²H₂)methyl]-4-hydroxyphenyl}hex-3-en-3-yl]phenol

IUPAC Traditional name

2-[(diethylamino)(²H₂)methyl]-4-[(3E)-4-{3-[(diethylamino)(²H₂)methyl]-4-hydroxyphenyl}hex-3-en-3-yl]phenol

Synonyms

4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol-d4

(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol-d4

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

Labelled NSC-33994 (N900300). NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.

REFERENCES

Tanner, J., et al.: J. Biol. Chem., 270, 6523 (1995)
Rane, S., et al.: Oncogene, 19, 5662 (2000, Verma, A., et al.: Cancer Metastasis Rev., 22, 423 (1995)
Levine, R., et al.: Cancer Cell., 7, 387 (1995)
Kiss, et al.: Bioorg. Med. Chem. Lett., 19, 3598