24-Nor Ursodeoxycholic Acid-d5 Methyl Ester

• Catalog No.: N865307
• M. F.: C24H40O4
• M. W.: 392.572
• Storage: Refrigerator, under inert atmosphere

SYNONYMS

• IUPAC name: methyl (3R)-3-[(1S,2S,5R,7R,9S,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyl(4,4,5,6,6-^2H₅)tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]butanoate
• IUPAC Traditional name: methyl (3R)-3-[(1S,2S,5R,7R,9S,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyl(4,4,5,6,6-^2H₅)tetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadecan-14-yl]butanoate
• Synonyms: (3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic-d5 Acid Methyl Ester

PROPERTIES

• Apperance: Off-whtie Solid
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: Refrigerator, under inert atmosphere

DETAILS

Description (English)

Labelled Ursodeoxycholic Acid (U850000) derivative. 24-norUrsodeoxycholic acid is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.

REFERENCES

• Seedorf, U., et al.: J. Biol. Chem., 269, 21277 (1994)
• Stolowich, N., et al.: Biochemistry, 36, 1719 (1994)