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Nolatrexed Dihydrochloride_Molecular_structure_CAS_152946-68-4)
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Nolatrexed Dihydrochloride

Catalog No. N635800 Name Toronto Research Chemicals
CAS Number 152946-68-4 Website http://www.trc-canada.com
M. F. C14H12N4OS Telephone +1 (416) 665-9696
M. W. 284.33628 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, -20°C Freezer, Under Inert Atmosphere Chembase ID: 175548

SYNONYMS

IUPAC name
2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3,4-dihydroquinazolin-4-one
IUPAC Traditional name
2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one
Synonyms
2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride
AG 337
Thymitaq

DATABASE IDS

CAS Number 152946-68-4

PROPERTIES

Melting Point >270°C (dec.)
Solubility Water
Apperance Off-White to Pale Yellow Solid
MSDS Link Download
Storage Condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Storage Warning Hygroscopic
Certificate of Analysis Download

DETAILS

Description (English)
Antifolate thymidylate synthase inhibitor. Antineoplastic.

REFERENCES

  • Webber, S.E., et al.: J. Med. Chem., 36, 733 (1993)
  • Rafi, I., et al.: Clin. Cancer Res., 1, 1275 (1993)
  • Dash, A.K., et al.: J. Pharm. Sci., 85, 1123 (1993)
  • Webber, S., et al.: Cancer Chemother. Pharmacol., 37, 509 (1993)
  • Stuart, K., et al.: Cancer, 86