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S-(4-Nitrobenzyl)-6-thioinosine _Molecular_structure_CAS_38048-32-7)
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S-(4-Nitrobenzyl)-6-thioinosine

Catalog No. N493695 Name Toronto Research Chemicals
CAS Number 38048-32-7 Website http://www.trc-canada.com
M. F. C17H17N5O6S Telephone +1 (416) 665-9696
M. W. 419.41178 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 175202

SYNONYMS

IUPAC name
(2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}-9H-purin-9-yl)oxolane-3,4-diol
IUPAC Traditional name
(2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}purin-9-yl)oxolane-3,4-diol
Synonyms
NSC 296962
6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine
NBMPR
6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

DATABASE IDS

CAS Number 38048-32-7

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Solid
Melting Point 177-180°C
Solubility DMSO
Solubility Ethyl Acetate
MSDS Link Download
Storage Condition Refrigerator

DETAILS

Description (English)
It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotect

REFERENCES

  • Krug, E., et al.: J. Biol. Chem., 264, 10601 (1989)
  • Griffiths, M., et al.: Biochem. J., 328, 739 (1989)
  • Zhu, Z., et al.: J. Med. Chem., 46, 831 (1989)
  • Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (1989)
  • Barnes, K., et al.: Circ. Res., 99, 510 (2006