S-(4-Nitrobenzyl)-6-thioinosine

• Catalog No.: N493695
• CAS Number: 38048-32-7
• M. F.: C17H17N5O6S
• M. W.: 419.41178
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}-9H-purin-9-yl)oxolane-3,4-diol
• IUPAC Traditional name: (2S,3R,4S,5S)-2-(hydroxymethyl)-5-(6-{[(4-nitrophenyl)methyl]sulfanyl}purin-9-yl)oxolane-3,4-diol
• Synonyms: NSC 296962; 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine; S-(p-Nitrobenzyl)-6-mercapto-9-β-D-ribofuranosylpurine; NBMPR; 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

DATABASE IDS

• CAS Number: 38048-32-7

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 177-180°C
• Solubility: DMSO
• Solubility: Ethyl Acetate
• Storage Condition: Refrigerator

DETAILS

Description (English)

It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotect

REFERENCES

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• Griffiths, M., et al.: Biochem. J., 328, 739 (1989)
• Zhu, Z., et al.: J. Med. Chem., 46, 831 (1989)
• Baldwin, S., et al.: J. Biol. Chem., 280, 15880 (1989)
• Barnes, K., et al.: Circ. Res., 99, 510 (2006