trans-Ned-19-d8

• Catalog No.: N388752
• M. F.: C30H31FN4O3
• M. W.: 514.5905432

SYNONYMS

• IUPAC name: (1R,3R)-1-(3-{[4-(2-fluorophenyl)(^2H₈)piperazin-1-yl]methyl}-4-methoxyphenyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid
• IUPAC Traditional name: (1R,3R)-1-(3-{[4-(2-fluorophenyl)(^2H₈)piperazin-1-yl]methyl}-4-methoxyphenyl)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid
• Synonyms: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-(piperazinyl-d8)]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid

DETAILS

Description (English)

Labelled trans-Ned-19, a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be

REFERENCES

• Rosen, D. et al.: J. Biol. Chem., 284, 34930 (2009)
• Naylor, E. et al.: Nat. Chem. Biol., 5, 220 (2009)
• Thai, T.L. et al.: Am. J. Physiol. Renal Physiol., 297, F510 (2009)