Nimbolide

• Catalog No.: N476300
• CAS Number: 25990-37-8
• M. F.: C27H30O7
• M. W.: 466.5229
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.0^2,^9.0^4,^8.0^1^5,^1^8]octadeca-7,13-dien-10-yl]acetate
• IUPAC Traditional name: methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.0^2,^9.0^4,^8.0^1^5,^1^8]octadeca-7,13-dien-10-yl]acetate
• Synonyms: NSC 309909; (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester

DATABASE IDS

• CAS Number: 25990-37-8

PROPERTIES

• Apperance: Light Beige Solid
• Melting Point: >223°C (dec.)
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong gr

REFERENCES

• Khalid, S., et al.: J. Nat. Prod., 52, 922 (1989)
• Cohen, E., et al.: J. Life Sci., 58, 1075 (1989)
• Moragoda, L., et al.: Anticancer Res., 21, 873 (1989)
• Chang, K., et al.: Biochem. Pharmacol., 67, 717 (1989)
• Parsels, L., et al.: Cancer Res., 64, 6588