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Nimbolide

Catalog No. N476300 Name Toronto Research Chemicals
CAS Number 25990-37-8 Website http://www.trc-canada.com
M. F. C27H30O7 Telephone +1 (416) 665-9696
M. W. 466.5229 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, -20°C Freezer, Under Inert Atmosphere Chembase ID: 175017

SYNONYMS

IUPAC name
methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate
IUPAC Traditional name
methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate
Synonyms
NSC 309909
(4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester

DATABASE IDS

CAS Number 25990-37-8

PROPERTIES

Certificate of Analysis Download
Apperance Light Beige Solid
Melting Point >223°C (dec.)
Solubility Chloroform
Solubility Ethyl Acetate
MSDS Link Download
Storage Condition Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong gr

REFERENCES

  • Khalid, S., et al.: J. Nat. Prod., 52, 922 (1989)
  • Cohen, E., et al.: J. Life Sci., 58, 1075 (1989)
  • Moragoda, L., et al.: Anticancer Res., 21, 873 (1989)
  • Chang, K., et al.: Biochem. Pharmacol., 67, 717 (1989)
  • Parsels, L., et al.: Cancer Res., 64, 6588