6β-Naltrexol 3-(2',3',4'-Tri-O-acetyl)-β-D-glucuronide Methyl Ester

• Catalog No.: N285715
• M. F.: C33H41NO13
• M. W.: 659.67754

SYNONYMS

• IUPAC name: methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-{[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-14,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-10-yl]oxy}oxane-2-carboxylate
• IUPAC Traditional name: methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-{[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-14,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-10-yl]oxy}oxane-2-carboxylate
• Synonyms: (5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-6,14-dihydroxy-morphinan-3-yl 3-(2’,3’,4’-Tri-O-acetyl)-β-D-glucuronide Methyl Ester

PROPERTIES

• Apperance: Yellow Solid
• Solubility: Dichloromethane
• Solubility: Methanol

DETAILS

Description (English)

Protected 6β-Naltrexol 3-O-β-D-Glucuronide (N285710). A metabolite of 6β-Naltrexol (N285700). Narcotic antagonist.

REFERENCES

• Portoghese, P. et al,: J. Med. Chem., 37, 579 (1994)
• Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1994)