Nalfurafine-d3 Hydrochloride

• Catalog No.: N255602
• M. F.: C28H33ClN2O5
• M. W.: 513.02502

SYNONYMS

• IUPAC name: (2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-14-yl]-3-(furan-3-yl)-N-(^2H₃)methylprop-2-enamide hydrochloride
• IUPAC Traditional name: (2E)-N-[(1S,5R,13R,14R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-14-yl]-3-(furan-3-yl)-N-(^2H₃)methylprop-2-enamide hydrochloride
• Synonyms: (2E)-N-[(5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide Hydrochloride; Remitch; (-)-17-(Cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan Hydrochloride; TRK 820

DETAILS

Description (English)

Nalfurafine hydrochloride was launched on March of 2009 in Japan as the first in class non-narcotic opioid drug for intractable itch caused by hemodialysis. It showed significant opioid κ-agonist activity and induced neither aversion nor preference in rat

REFERENCES

• Fujii, H., et al.: Bioorg. Med. Chem., 12, 4133 (2004)
• Mori, T., et al.: Life Sci., 75, 2433 (2004)
• Fujii, H., et al.: Curr. Med. Chem., 13, 1109 (2004)
• Nagase, H., et al.: Bioorg. Med. Chem. Lett., 20, 6302 (2004)