MLN 4924

• Catalog No.: M425100
• CAS Number: 905579-51-3
• M. F.: C21H25N5O4S
• M. W.: 443.5193
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: [(1S,2R,4R)-4-(4-{[(1S)-2,3-dihydro-1H-inden-1-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl]methyl sulfamate
• IUPAC Traditional name: [(1S,2R,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate
• Synonyms: Sulfamic Acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl Ester

DATABASE IDS

• CAS Number: 905579-51-3

PROPERTIES

• Apperance: White Solid
• Melting Point: 148-150°C
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins.

REFERENCES

• Haas, A., et al.: J. Biol. Chem., 257, 10329 (1982)
• Walden, H., et al.: Nature, 422, 330 (1982)
• Kane, R., et al.: Clin. Cancer Res., 13, 5291 (1982)
• Saha, A., et al.: Mol. Cell., 32, 21 (1982)