MK-2206 Dihydrochloride

• Catalog No.: M425025
• CAS Number: 1032350-13-2
• M. F.: C25H21N5O
• M. W.: 407.46714

SYNONYMS

• IUPAC name: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H,3H-[1,2,4]triazolo[3,4-f]1,6-naphthyridin-3-one
• IUPAC Traditional name: 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f]1,6-naphthyridin-3-one
• Synonyms: 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride

DATABASE IDS

• CAS Number: 1032350-13-2

DETAILS

Description (English)

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearin

REFERENCES

• Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007)
• Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2007)