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MK-886 Sodium Salt_Molecular_structure_CAS_118427-55-7)
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MK-886 Sodium Salt

Catalog No. M425000 Name Toronto Research Chemicals
CAS Number 118427-55-7 Website http://www.trc-canada.com
M. F. C27H33ClNNaO2S Telephone +1 (416) 665-9696
M. W. 494.06419 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Hygroscopic, Refrigerator, Under Inert Atmosphere Chembase ID: 174665

SYNONYMS

IUPAC name
sodium 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoate
IUPAC Traditional name
sodium 3-[3-(tert-butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-isopropylindol-2-yl]-2,2-dimethylpropanoate
Synonyms
3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid Sodium Salt
L 663536 Sodium Salt
1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoic Acid Sodium Salt

DATABASE IDS

CAS Number 118427-55-7

PROPERTIES

Certificate of Analysis Download
Apperance White Solid
Melting Point 295-297°C
Solubility Dichloromethane
Solubility Ethanol
Solubility Methanol
MSDS Link Download
Storage Condition Hygroscopic, Refrigerator, Under Inert Atmosphere

DETAILS

Description (English)
MK-886 is a leukotriene inhibitor. MK-886 and Celecoxib have an inhibitory effect on the growth of pancreatic cancer cell line SW1990 and angiogenesis.

REFERENCES

  • Dixon, R.A.F., et al.: Nature, 343, 282 (1990)
  • Kargman, S., et al.: J. Biol. Chem., 266, 23745 (1990)
  • Ford-Hutchinson, A.W., et al.: Trends Pharmacol. Sci., 12, 63 (1990)