Dextrothyroxine

• Catalog No.: DB00509
• CAS Number: 51-49-0
• M. F.: C15H11I4NO4
• M. W.: 776.87002

SYNONYMS

• IUPAC name: 2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
• IUPAC Traditional name: thyroxine
• Brand Name: Eulipos; Choloxin; Dynothel; Lisolipin
• Synonyms: D-Thyroxine Sodium; Dextrotyroxinnatrium; Dextrothyroxinum Natricum; Sodium 4-O-(4-hydroxy-3,5-di-iodophenyl)-3,5-di-iodo-d-tyrosinate hydrate; 3,5,3′,5′-Tetraiodo-d-thyronine Sodium; Dekstrotyroksiininatrium; Dextrotiroxina sódica

DATABASE IDS

• CAS Number: 51-49-0

PROPERTIES

• Hydrophobicity(logP): 4

DETAILS

Description (English)

• Drug Groups: approved
• Description: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
• Indication: Used to lower high cholesterol levels in the blood.
• Pharmacology: Dextrothyroxine, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic.
• Toxicity: Symptoms of dextrothyroxine overdose are unknown.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia