N-Methyl Naltrexone-d3 Bromide

• Catalog No.: M320352
• M. F.: C21H26BrNO4
• M. W.: 436.33944
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,4R,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-4-(^2H₃)methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-4-ium bromide
• IUPAC Traditional name: (1S,4R,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-4-(^2H₃)methyl-14-oxo-12-oxa-4-azapentacyclo[9.6.1.0^1,^1^3.0^5,^1^7.0^7,^1^8]octadeca-7(18),8,10-trien-4-ium bromide
• Synonyms: Naltrexone Methyl-d3 Bromide; N-Cyclopropylmethyl-noroxymorphone Methobromide-d3; Relistor-d3; MRZ 2663BR-d3; (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-(methyl-d3)-6-oxomorphinanium Bromide; Methylnaltrexone-d3; Methylnaltrexone-d3 Bromide; N-Methylnaltrexone-d3 Bromide; Naltrexone Methobromide-d3

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 240-242°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A labelled metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX), a selective μ-opioid receptor antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract.

REFERENCES

• Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984)
• Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (1984)