α-Methyl-γ-hydroxy-1,N2-propano-2'-deoxyguanosine-13C,15N2(Mixture of Diastereomers)

• Catalog No.: M312892
• M. F.: C14H19N5O5
• M. W.: 340.31063263
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 8-hydroxy-3-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl(4a-^1^3C,5,9-^1^5N₂)-3H,5H,6H,7H,8H,10H-pyrimido[1,2-a]purin-10-one
• IUPAC Traditional name: 8-hydroxy-3-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-methyl(4a-^1^3C,5,9-^1^5N₂)-5H,6H,7H,8H-pyrimido[1,2-a]purin-10-one
• Synonyms: α-Me-γ-OH-PdG-13C,15N2; Cr-PdG-13C,15N2; 3-(2-Deoxy-β-D-erythro-pentofuranosyl)-4,6,7,8-tetrahydro-8-hydroxy-6-methylpyrimido[1,2-a]purin-10(3H)-one-13C,15N2

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 149-152°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A genotoxic labelled cyclic adduct of 2'-deoxyguanosine with crotonaldehyde. Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde.

REFERENCES

• Fang, J., et al.: Carcinogenesis, 18, 627 (1997)
• Wang, M., et al.: Chem. Res. Toxicol., 14, 1025 (1997)
• Kurtz, A., et al.: J. Biol. Chem., 278, 5970 (1997)