3-O-Methyl-L-DOPA Monohydrate

• Catalog No.: M303815
• CAS Number: 200630-46-2
• M. F.: C10H15NO5
• M. W.: 229.2298
• Storage: Hygroscopic, Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2S)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid hydrate
• IUPAC Traditional name: 3-methoxytyrosine hydrate
• Synonyms: 3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-O-Methyl-DOPA Monohydrate; L-4-Hydroxy-3-methoxyphenylalanine Monohydrate; 3-O-Methyldopa Monohydrate; 3-Methoxy-L-tyrosine Monohydrate; 3-Methoxy-DOPA Monohydrate

DATABASE IDS

• CAS Number: 200630-46-2

PROPERTIES

• Apperance: Pale Brown Solid
• Melting Point: 223-225°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, Refrigerator, Under Inert Atmosphere

DETAILS

Description (English)

3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity o

REFERENCES

• Soares-da Silva, P., et al.: Brain Res., 863, 293 (2000)
• Deleu, D., et al.: Clin. Pharmacokinet., 41, 261 (2000)