12-O-Methyl Clarithromycin

• Catalog No.: M294630
• CAS Number: 128940-83-0
• M. F.: C39H71NO13
• M. W.: 761.97994

SYNONYMS

• IUPAC name: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• IUPAC Traditional name: (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
• Synonyms: 6,12-Di-O-methylerythromycin A; 6,12-Di-O-methylerythromycin; Clarithromycin EP Impurity F

DATABASE IDS

• CAS Number: 128940-83-0

DETAILS

Description (English)

12-O-Methyl Clarithromycin is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells.

REFERENCES

• Chen, X. et al.: Zhong. Yao., 17, 32 (2008)
• Yoshida, H. et al.: Jap. J. Antibiot., 53, 615 (2008)
• Omura, S. et al.: Yakug. Zas., 112, 593 (2008)