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12-O-Methyl Clarithromycin_Molecular_structure_CAS_128940-83-0)
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12-O-Methyl Clarithromycin

Catalog No. M294630 Name Toronto Research Chemicals
CAS Number 128940-83-0 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
IUPAC Traditional name
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12-hydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7,13-dimethoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione
Synonyms
6,12-Di-O-methylerythromycin A
6,12-Di-O-methylerythromycin
Clarithromycin EP Impurity F

DATABASE IDS

CAS Number 128940-83-0

PROPERTIES

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DETAILS

Description (English)
12-O-Methyl Clarithromycin is a methylated impurity of the semi-synthetic macrolide antibiotic Clarithromycin (C559750). 12-O-Methyl Clarithromycin was shown to inhibit uptake of Clarithromycin into the lung cells.

REFERENCES

  • Chen, X. et al.: Zhong. Yao., 17, 32 (2008)
  • Yoshida, H. et al.: Jap. J. Antibiot., 53, 615 (2008)
  • Omura, S. et al.: Yakug. Zas., 112, 593 (2008)