7-Methyl Camptothecin

• Catalog No.: M294565
• CAS Number: 78287-26-0
• M. F.: C21H18N2O4
• M. W.: 362.37862

SYNONYMS

• IUPAC name: (19S)-19-ethyl-19-hydroxy-10-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-19-ethyl-19-hydroxy-10-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (4S)-4-Ethyl-4-hydroxy-11-methyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione; 7-Methyl-20(S)-camptothecin; 7-Methylcamptothecin

DATABASE IDS

• CAS Number: 78287-26-0

DETAILS

Description (English)

Camptothecin analog as DNA topoisomerase I inhibitors: a QSAR study. It may also be useful in the design and development of new camptothecin derivatives as DNA topoisomerase I (topo I) inhibitors. A poorly water soluble camptothecin analogue. Antitumor ag

REFERENCES

• Staker, B., et al.: J. Med. Chem., 48, 2336 (2005)
• Verma, R., et al.: Bioorg. Med. Chem., 13, 1059 (2005)