2-Methoxy-d3 17β-Estradiol

• Catalog No.: M262627
• M. F.: C19H26O3
• M. W.: 302.40794

SYNONYMS

• IUPAC name: (14S,15S)-4-(^2H₃)methoxy-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2(7),3,5-triene-5,14-diol
• IUPAC Traditional name: (14S,15S)-4-(^2H₃)methoxy-15-methyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2(7),3,5-triene-5,14-diol
• Synonyms: 2-Methoxy-d3-estra-1,3,5(10)-triene-3,17β-diol; (17β)-2-Methoxy-d3-estra-1,3,5(10)-triene-3,17-diol; 2-Hydroxyestradiol 2-Methyl-d3 Ether; 2-Methoxy-d3-estradiol; NSC 659853-d3; Panzem-d3

PROPERTIES

• Apperance: Crystalline Solid
• Melting Point: 188-190°C
• Solubility: Dichloromethane

DETAILS

Description (English)

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembl

REFERENCES

• Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995)
• D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1995)
• Forsis, T., et al.: Nature, 368, 237 (1994)