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Methotrexate

Catalog No. M260675 Name Toronto Research Chemicals
CAS Number 59-05-2 Website http://www.trc-canada.com
M. F. C20H22N8O5 Telephone +1 (416) 665-9696
M. W. 454.43928 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 445

SYNONYMS

IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
IUPAC Traditional name
methotrexate
Synonyms
CL 14377
R 9985
Mexate
4-Amino-N10-methylfolic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid
L-Metatrexan
(+)-Amethopterin
4-Amino-N10-methylpteroylglutamic Acid
Antifolan
EMT 25299
Emtexate
Ledertrexate
MTX
Methylaminopterin
Rheumatrex
Trexall
NSC 740

DATABASE IDS

CAS Number 59-05-2

PROPERTIES

Certificate of Analysis Download
Apperance Yellow Solid
Melting Point >188°C (dec.)
Solubility DMSO
MSDS Link Download
Storage Condition Refrigerator
Storage Warning Hygroscopic

DETAILS

Description (English)
A Folic acid antagonist. Used as a antineoplastic and antirheumatic.

REFERENCES

  • Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958)
  • Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1958)