L-Methionine [R,S]-Sulfoximine

• Catalog No.: M260500
• CAS Number: 15985-39-4
• M. F.: C5H12N2O3S
• M. W.: 180.22538
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2S)-2-amino-4-[imino(methyl)oxo-λ^6-sulfanyl]butanoic acid
• IUPAC Traditional name: L-methionine sulfoximine
• Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid

DATABASE IDS

• CAS Number: 15985-39-4

PROPERTIES

• Apperance: White Solid
• Melting Point: >210°C (dec.)
• Solubility: Water
• Storage Condition: -20°C Freezer
• Storage Warning: Temperature Sensitive

DETAILS

Description (English)

Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic by

REFERENCES

• Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979)
• Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)