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(+)-α-Methadol

Catalog No. M225860 Name Toronto Research Chemicals
CAS Number 17199-54-1 Website http://www.trc-canada.com
M. F. C21H29NO Telephone +1 (416) 665-9696
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Storage Chembase ID: 172703

SYNONYMS

IUPAC name
(3R,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-ol
IUPAC Traditional name
(3R,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-ol
Synonyms
(3R,6R)-(+)-6-(Dimethylamino)-4,4-diphenyl-3-Heptanol
D-α-Methadol
Alphamethadol
(αR)-β-[(2R)-2-(Dimethylamino)propyl]-α-ethyl-β-phenylbenzeneethanol

DATABASE IDS

CAS Number 17199-54-1

PROPERTIES

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DETAILS

Description (English)
A reduction product of (R)-Methadone. Analgesic. The enatiomer of (-)-α-Methadol (M225861) and is less effective in binding to opiate receptors. The relative activities of (-)-α-Methadol and (+)-α-Methadol are reversed upon acetylation.

REFERENCES

  • Portoghese, P.S., et al.: J. Med. Chem., 12, 839 (1969)
  • Ruemmler, R., et al.: Arzneim.-Forsch., 20, 281 (1969)
  • Horng, J.S. et al.: Res. Comm. Chem. Pathol. Pharmacol., 14, 621 (1969)
  • Casy, A.F. et al.: J. Med. Chem., 11, 601 (1969)