Mafosfamide Sodium Salt

• Catalog No.: M110300
• CAS Number: 84211-05-2
• M. F.: C9H18Cl2N2NaO5PS2
• M. W.: 423.249151
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: sodium 2-{[(2R,4R)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ^5-oxazaphosphinan-4-yl]sulfanyl}ethane-1-sulfonate
• IUPAC Traditional name: sodium 2-{[(2R,4R)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ^5-oxazaphosphinan-4-yl]sulfanyl}ethanesulfonate
• Synonyms: Mafosfamid Sodium; rel-2-[[(2R,4R)-2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl]thio]ethanesulfonic Acid Sodium; cis-Mafosfamide Sodium; Z 7557

DATABASE IDS

• CAS Number: 84211-05-2

PROPERTIES

• Apperance: White Solid
• Melting Point: >145°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A Cyclophosphamide analog which induces apoptosis dose and time dependently in lymphoblastoid cells, with clearly more apoptosis in p53wt cells. Antitumor agent.

REFERENCES

• Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999)
• Lips, J., et al.: Carcinogenesis, 22, 579 (1999)
• Ward, I., et al.: J. Biol. Chem., 276, 47759 (1999)
• Zhou, B., et al.: Cancer Biol. Ther., 2, S16 (1999)
• Roos, W., et al.: Oncogene, 26, 186 (1999)