L-744832

• Catalog No.: L744832
• CAS Number: 1177806-11-9
• M. F.: C26H45N3O6S2
• M. W.: 559.782
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: propan-2-yl (2S)-2-[(2S)-2-{[(2S,3R)-2-{[(2R)-2-amino-3-sulfanylpropyl]amino}-3-methylpentyl]oxy}-3-phenylpropanamido]-4-methanesulfonylbutanoate
• IUPAC Traditional name: isopropyl (2S)-2-[(2S)-2-{[(2S,3R)-2-{[(2R)-2-amino-3-sulfanylpropyl]amino}-3-methylpentyl]oxy}-3-phenylpropanamido]-4-methanesulfonylbutanoate
• Synonyms: (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride

DATABASE IDS

• CAS Number: 1177806-11-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 165-168°C
• Solubility: Acetonitrile
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

REFERENCES

• Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998)
• Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998)
• Law, B.K., et al.: J. Biol. Chem., 275, 10796 (1998)