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LY 2228820-d9
Catalog No.	L486502	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C25H33FN6	Telephone	+1 (416) 665-9696
M. W.	436.5681232	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 172439

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SYNONYMS

IUPAC name

3-(2,2-dimethylpropyl)-5-[4-(4-fluorophenyl)-2-[2-(²H₃)methyl(²H₆)propan-2-yl]-1H-imidazol-5-yl]-3H-imidazo[4,5-b]pyridin-2-amine; methane

IUPAC Traditional name

3-(2,2-dimethylpropyl)-5-[5-(4-fluorophenyl)-2-[2-(²H₃)methyl(²H₆)propan-2-yl]-3H-imidazol-4-yl]imidazo[4,5-b]pyridin-2-amine; methane

Synonyms

5-[2-(1,1-Dimethylethyl-d9)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

Laballed LY2228820, a novel and potent p38MAPK inhibitor with potent antiinflammatory activity. LY2228820 significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMS

REFERENCES

Zhao, R. et al.: Drug Metab. Disp., 37, 1251 (2009)
Ishitsuka, K. et al.: Br. J. Haematol., 141, 598 (2009)
Mader, M. et al.: Bioorg. Med. Chem. Lett., 18, 179 (2009)