β-Lumi (-)-Colchicine

• Catalog No.: L474300
• CAS Number: 6901-13-9
• M. F.: C22H25NO6
• M. W.: 399.437
• Storage: Amber Vial, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: N-[(10S,12R,16S)-3,4,5,14-tetramethoxy-13-oxotetracyclo[9.5.0.0^2,^7.0^1^2,^1^6]hexadeca-1(11),2(7),3,5,14-pentaen-10-yl]acetamide
• IUPAC Traditional name: N-[(10S,12R,16S)-3,4,5,14-tetramethoxy-13-oxotetracyclo[9.5.0.0^2,^7.0^1^2,^1^6]hexadeca-1(11),2(7),3,5,14-pentaen-10-yl]acetamide
• Synonyms: Lumicolchicine; β-Lumi-(-)-colchicine; NSC 56233; N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide; β-Lumicolchicine; (-)-β-Lumicolchicine; NSC 221661

DATABASE IDS

• CAS Number: 6901-13-9

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 177-180°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Amber Vial, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An analog of Colchicine (C640000), β-lumicolchicine, does not bind tubulin or disrupt microtubules. A GABAA receptor chloride channel.

REFERENCES

• Andreu, J., et al.: Biochemistry, 37, 8356 (1998)
• Weiner, J., et al.: J. Pharmacol. Exp. Ther., 284, 95 (1998)
• Hong, G., et al.: J. Pharm. Sci., 88, 147 (1998)