Lopinavir-d8

• Catalog No.: L469482
• M. F.: C37H48N4O5
• M. W.: 628.80082
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-(^2H₃)methyl-2-(2-oxo-1,3-diazinan-1-yl)(^2H₅)butanamide
• IUPAC Traditional name: N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-(^2H₃)methyl-2-(2-oxo-1,3-diazinan-1-yl)(^2H₅)butanamide
• Synonyms: (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide-d8; A 157378.0-d8; Aluviran-d8; Koletra-d8; ABT 378-d8

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 97-99°C
• Solubility: Chloroform
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A labelled selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral.

REFERENCES

• Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998)
• Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1998)
• Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)