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Lometrexol  _Molecular_structure_CAS_106400-81-1)
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Lometrexol

Catalog No. L469465 Name Toronto Research Chemicals
CAS Number 106400-81-1 Website http://www.trc-canada.com
M. F. C21H25N5O6 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
(2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4H,4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
IUPAC Traditional name
(2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
Synonyms
N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid
LY 264618

DATABASE IDS

CAS Number 106400-81-1

PROPERTIES

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DETAILS

Description (English)
It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.

REFERENCES

  • Gibbs, D., et al.: Cancer Res., 65, 11721 (2005)
  • Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005)
  • Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005)