Lometrexol

• Catalog No.: L469465
• CAS Number: 106400-81-1
• M. F.: C21H25N5O6
• M. W.: 443.4531

SYNONYMS

• IUPAC name: (2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4H,4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
• IUPAC Traditional name: (2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-4aH,5H,6H,7H,8H-pyrido[2,3-d]pyrimidin-6-yl]ethyl}phenyl)formamido]pentanedioic acid
• Synonyms: N-[4-[2-[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-L-glutamic Acid; LY 264618

DATABASE IDS

• CAS Number: 106400-81-1

DETAILS

Description (English)

It is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo purine synthesis. Lometrexol has activity against tumors which are refractory to other drugs, notably Methotrexate.

REFERENCES

• Gibbs, D., et al.: Cancer Res., 65, 11721 (2005)
• Gangjee, A., et al.: J. Med. Chem., 48, 5329 (2005)
• Hilgenbrink, A., et al.: J. Pharm. Sci., 94, 2135 (2005)