(S)-Lofexidine

• Catalog No.: L469400
• CAS Number: 81447-79-2
• M. F.: C19H26I3N3O9
• M. W.: 821.13785

SYNONYMS

• IUPAC name: 5-{N-[dihydroxy(^2H₅)propyl]acetamido}-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
• IUPAC Traditional name: 5-{N-[dihydroxy(^2H₅)propyl]acetamido}-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
• Synonyms: (+)-Lofexidine; Dexlofexidine; 2-[(1S)-1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole

DATABASE IDS

• CAS Number: 81447-79-2

DETAILS

Description (English)

The S-enantiomer of Lofexidine. α2-Adrenoceptor agonist related structurally to Clonidine. Used in treatment of opioid withdrawal symptoms; antihypertensive.

REFERENCES

• Velly, J., et al.: J. Pharmacol., 8, 351 (1977)
• Jarrot, B., et al.: Biochem. Pharmacol., 28, 141 (1977)
• Birch, P., at al.: Brit. J. Pharmacol., 68, 107 (1977)