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Limaprost

Catalog No. L461500 Name Toronto Research Chemicals
CAS Number 74397-12-9 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
(2E)-7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl]hept-2-enoic acid
IUPAC Traditional name
limaprost
Synonyms
17S,20-Dimethyl-trans-Δ2-PGE1
(2E,11α,13E,15S,17S)-11,15-Dihydroxy-17,20-dimethyl-9-oxo-prosta-2,13-dien-1-oic Acid
(2E)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonen-1-yl]-5-oxocyclopentyl]-2-heptenoic Acid
ONO 1206
OP 1206

DATABASE IDS

CAS Number 74397-12-9

PROPERTIES

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DETAILS

Description (English)
Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.

REFERENCES

  • Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980)
  • Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1980)
  • Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1980)
  • Ishizaki, T., et al.: Chest, 85, 382 (1980)