Leurosine Sulfate

• Catalog No.: L330800
• CAS Number: 54081-68-4
• M. F.: C46H56N4O9
• M. W.: 808.95824
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.0^4,^1^2.0^5,^1^0.0^1^6,^1^8]icosa-4(12),5,7,9-tetraene-13-carboxylate
• IUPAC Traditional name: methyl (1S,13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.0^4,^1^2.0^5,^1^0.0^1^6,^1^8]icosa-4(12),5,7,9-tetraene-13-carboxylate
• Synonyms: Lilly 32645; Vinleurosine Sulfate; 4β-Acetoxy-3’α,4’-epoxy-3-hydroxy-16-methoxy-(4’α H)-vincaleukoblast-6-ene-23,22’-dioic Acid Dimethyl Ester Sulfate

DATABASE IDS

• CAS Number: 54081-68-4

PROPERTIES

• Apperance: Light Yellow Solid
• Melting Point: >200°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A new antitumor derivative of Vinblastine; a dimeric Vinca alkaloid for cancer therapy.

REFERENCES

• Chakravarty, et al.: J. Med. Chem., 26(5)
• 638 (5)
• Christensson., et al.: Eu.r J. Biochem., 194, 755 (5)
• Mayer, et al.: J. Med. Chem., 34, 3029 (5)
• Yu, H., et al.: Clin. Biochem., 27, 75 (1994)