Home > Compound List > Product Information
Leflunomide_Molecular_structure_CAS_75706-12-6)
Click picture or here to close

Leflunomide

Catalog No. L322750 Name Toronto Research Chemicals
CAS Number 75706-12-6 Website http://www.trc-canada.com
M. F. C12H9F3N2O2 Telephone +1 (416) 665-9696
M. W. 270.2072696 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 968

SYNONYMS

IUPAC name
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
IUPAC Traditional name
leflunomide
Synonyms
5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Leflunomidum
Leflunomida
5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]

DATABASE IDS

CAS Number 75706-12-6

PROPERTIES

Certificate of Analysis Download
Apperance Off White Solid
Melting Point 153-156°C
Solubility Dichloromethane
Solubility Ether
Solubility Ethyl Acetate
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical

REFERENCES

  • Vrenken, T., et al.: J. Hepatol., 49, 799 (2008)
  • Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008)
  • Davies, M., et al.: J. Med. Chem., 52, 2683 (2008)