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(S)-Laudanosine

Catalog No. L178525 Name Toronto Research Chemicals
CAS Number 2688-77-9 Website http://www.trc-canada.com
M. F. C21H27NO4 Telephone +1 (416) 665-9696
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SYNONYMS

IUPAC name
(1S)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
IUPAC Traditional name
laudanosine
Synonyms
(+)-Laudanosine,
(1S)-1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline
L-(+)-Laudanosine
L-Laudanosine
(+)-Laudanosine
(S)-(+)-Laudanosine
(S)-Laudanosine
NSC 35045
O-Methylcodamine
Laudanosine

DATABASE IDS

CAS Number 2688-77-9

PROPERTIES

Certificate of Analysis Download
MSDS Link Download

DETAILS

Description (English)
Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.

REFERENCES

  • Canfell, P., et al.: Drug Metab. Dispos., 14, 703 (1986)
  • Anselmi, E., et al.: J. Pharm. Pharmacol., 44, 337 (1986)
  • Bohrer, H., et al.: Pharmacol. Toxicol., 73, 137 (1986)