Larotaxel

• Catalog No.: L176000
• CAS Number: 156294-36-9
• M. F.: C45H53NO14
• M. W.: 831.90062
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,9S,11R,13S,16S)-4,13-bis(acetyloxy)-16-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0^3,^1^1.0^4,^7.0^9,^1^1]octadec-14-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,3R,4S,7R,9S,11R,13S,16S)-4,13-bis(acetyloxy)-16-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl]oxy}-1-hydroxy-15,18,18-trimethyl-12-oxo-6-oxapentacyclo[12.3.1.0^3,^1^1.0^4,^7.0^9,^1^1]octadec-14-en-2-yl benzoate
• Synonyms: PNU 100940; (αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (1S,2S,4S,7R,8aR,9aS,10aR,12aS,12bR)-7,12a-Bis(acetyloxy)-1-(benzoyloxy)-1,3,4,7,8,9,9a,10,10a,12,12a,12b-dodecahydro-2-hydroxy-5,13,13-trimethyl-8-oxo-2,6-methano-2H-cyclodeca[3,4]cyclopropa[4,5]benz[1,2-b]oxet-4-yl Ester

DATABASE IDS

• CAS Number: 156294-36-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 180-182°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Larotaxel (RPR 109881A) is a taxane analog with a broad spectrum of activity and different toxicity profile and with the possible advantages of surpassing some mechanisms of resistance and penetrating into the CNS.

REFERENCES

• Kurata, T., et al.: J. Clin. Oncol., 18, 3164 (2000)
• Kemper, E., et al.: Eur. J. Cancer, 40, 1269 (2000)
• Nyman, D., et al.: J. Clin. Oncol., 23, 7785 (2000)